Synergistic effects of ovine-derived cathelicidins and other antimicrobials against Escherichia coli O157:H7 and Staphylococcus aureus 1056 MRSA |
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| Authors: | Danitsja S van der Linden David Short Antje Dittmann and Pak-Lam Yu |
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| Institution: | (1) Biotechnology Group, School of Engineering and Advanced Technology, Massey University, Private Bag 11-222, Palmerston North, 4442, New Zealand |
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| Abstract: | Synergistic effects of ovine-derived cathelicidins SMAP29 and OaBac5mini with the antimicrobials polymyxin B, lysozyme, nisin
and lactoferrin were investigated against E. coli O157:H7 and S. aureus 1056 MRSA. Lysozyme showed synergy against E. coli O157:H7 with SMAP29, polymyxin B and lactoferrin. Synergy was also found between SMAP29 and lactoferrin against this host.
Against S. aureus 1056 MRSA, lysozyme showed synergy with OaBac5mini, polymyxin B and nisin, while synergy was also found between nisin and
OaBac5mini and polymyxin B. Other combinations of the antimicrobials were either additive or non-synergistic. |
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| Keywords: | Cathelicidins Lactoferrin Lysozyme Nisin Polymyxin |
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