Isolation of nitrogen deregulated mutants of erythromycin biosynthesis |
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Authors: | Ma Elena Flores C |
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Institution: | (1) Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 04510 México, D.F., México |
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Abstract: | Summary Ammonium represses erythromycin synthesis bySaccharopolyspora erythraea and insensitive mutants to this effect were isolated. Six mutants were selected and one of them produces 50% more antibiotic than the wild type in 100 mM NH4Cl as nitrogen source. Glutamine synthetase and alanine dehydrogenase levels in the mutants were determined and no differences with wild type strain were observed. |
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