| 甲状腺素对人体缺血/再灌注心肌能量代谢酶影响的定性定量研究 |
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| 引用本文： | 张成立,孙宗全,蔡俊坚,蓝鸿钧,张艳,付平,董念国,熊希凯.甲状腺素对人体缺血/再灌注心肌能量代谢酶影响的定性定量研究[J].中国组织化学与细胞化学杂志,1999(4). |
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| 作者姓名： | 张成立 孙宗全 蔡俊坚 蓝鸿钧 张艳 付平 董念国 熊希凯 |
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| 作者单位： | 河南省南阳市心脏外科中心!南阳473058(张成立)，同济医科大学附属协和医院!武汉430022(孙宗全，蔡俊坚，蓝鸿钧，付平，董念国)，同济医科大学解剖学教研室!武汉430022(张艳)， (熊希凯) |
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| 摘 要： | 用酶组织化学方法检测了缺血／再灌注心肌ＬＤＨ、ＣＣＯ、ＳＤＨ、Ｃａ－ＡＴＰａｓｅ 活性； 分组研究甲状腺素（ＴＨ） 对围术期心肌能量代谢的影响。结果： 用药组ＳＤＨ、ＣＣＯ、Ｃａ－ＡＴＰａｓｅ 的活性比对照组增高， 两组ＬＤＨ无差异； 对照组１ 例死亡， 术前、术中、术后ＳＤＨ、ＣＣＯ、ＬＤＨ、Ｃａ－ＡＴＰａｓｅ 的活性显著降低。结论： 术前补充ＴＨ， 可提高心肌的有氧代谢， 能量合成， 促进心功能； 如果术前能了解心肌各酶活性， 将对手术适应症的选择提供帮助
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| 关 键 词： | 酶组织化学法 甲状腺素(TH) 围术期 琥珀酸脱氢酶(SDH) 细胞色素氧化酶(CCO) 乳酸脱氢酶(LDH) 钙ATP酶(Ca-ATPase) 缺血/再灌注 人 |
EFFECTS OF THYROXINE ON ENZYME OF MYOCARDIAL ENERGY METABOLISM DURING ISCHEMIC/REPEREUSION |
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| Zhang Chengli ,Sun Zongquan ,Xiong Xikai ,et al.EFFECTS OF THYROXINE ON ENZYME OF MYOCARDIAL ENERGY METABOLISM DURING ISCHEMIC/REPEREUSION[J].Chinese Journal of Histochemistry and Cytochemistry,1999(4). |
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| Authors: | Zhang Chengli Sun Zongquan Xiong Xikai |
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| Institution: | Zhang Chengli 1,Sun Zongquan 2,Xiong Xikai 2,et al |
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| Abstract: | The activities of LDH, CCO, SDH, Ca ATPase of human cardial myocyte during ischemia/reperfusion were detected with the histochemistry method in order to study the effects of thyroxine on the myocyte energetic metabolism in perioperation. The activities of CCO, SDH, Ca ATPase in the treated group were stronger than those in the control group, and that of in LDH there in was no difference in the two groups. The activities of SDH, CCO, LDH and Ca ATPase declined in one death case in the control group. It was concluded that pre treatment with thyroxine 4-7 days before operation could improve the aerobic metabolism, energetic synthesis of myocyte, and heart function. If the quantity of the myocyte metabolic enzyme was checked out before operation, it can give a hand to deciding the indication of the operation. |
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| Keywords: | Enzyme histochemistry TH Perioperation SDH CCO LDH Ca ATPase Ischemia/reperfusion Human |
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