肾上腺素受体拮抗剂对大鼠急性肝损害影响的研究

雄性ＳＤ大鼠３３只，体重１８０—２５０ｇ，随机分成四组。正常对照组６只；哌唑嗪组８只，于实验第１、２、３日上午用哌唑嗪灌胃（１ｍｇ／ｋｇ体重）共３次，第２日下午腹腔注射半乳糖胺（６００ｍｇ／ｋｇ体重）１次，第４日上午处死动物，取肝脏及血清作有关检查；普萘洛尔组及Ｎ．Ｓ对照组分别用普萘洛尔（２ｍｇ／ｋｇ体重）及Ｎ．Ｓ（１０ｍｌ／ｋｇ体重）代替哌唑嗪灌胃，处理程序同哌唑嗪组。结果表明：一、哌唑嗪能显著减轻肝脏病变及血清ＡＬＴ的升高。二、哌唑嗪对肝损害后肝组织ＳＤＨ、Ｍｇ２＋－ＡＴ－Ｐａｓｅ、ＣｈＥ、ＡＣＰ、ＣＣｏ等酶活性的恢复有显著效果。三、哌唑嗪组ＬＰＯ明显低于Ｎ．Ｓ对照组（Ｐ＜０．０１）而ＳＯＤ活性明显高于Ｎ．Ｓ对照组（Ｐ＜０．０１）。普萘洛尔组各项指标同对照组比较均无显著差异（Ｐ＞０．０５）。提示：哌唑嗪对大鼠实验性肝损害有一定的保护作用。

A STUDY OF THE EFFECT OF ADRENALIN RECEPTOR ANTAGONIST ON ACUTE LIVER INJURY IN RATS

Tostudy the relationship between liver injury and adrenalin receptor antagonist, the histochemical, serum ALT, LPO and SOD changes were investigated in the livers of 33 rats.The rats were divided into 4 groups and treated as follows: 1. normal group; 2. prazozin group, giving prazosin 1 time every day for 3 days by stomach-tube; 3. propranolol group;4. experimental control group. Propranolol and NS were used to replace prazosin. The results indicated that the prazosin significantly decreased the level of serum ALT (P<0. 05)and liver injury. the prazosin was effective in the recovery of enzyme activities on acute liver injury such as SDH, ACP, Mg2+--ATPase,ChE, CCo etc. The LPO was lower and SOD higher (P<0. 01) in the liver of prazosin group. Compared with the experimental control group all the indeedes of the propranolol group .showed no remarkable differences, These findings suggest that the adrenalin receptor antagonists may play an important role in preventing experimental injury of the liver.