| 血管内皮生长因子-C与乳腺癌淋巴管生成和淋巴结转移的关系 |
| |
| 引用本文： | 梁运霞,陈茂怀,黄博.血管内皮生长因子-C与乳腺癌淋巴管生成和淋巴结转移的关系[J].中国组织化学与细胞化学杂志,2008,17(6):594-598. |
| |
| 作者姓名： | 梁运霞 陈茂怀 黄博 |
| |
| 作者单位： | 汕头大学医学院病理学教研室,汕头,515031 |
| |
| 摘 要： | 目的探讨血管内皮生长因子-C与乳腺癌淋巴管生成和淋巴结转移的关系。方法免疫组化法检测21例乳腺增生组和68例乳腺浸润性导管癌组病灶组织内VEGF-C蛋白的表达，并用淋巴管内皮细胞特异性标志物D2-40标记肿瘤新生淋巴管，计数肿瘤淋巴管的密度（LVD）。结果乳腺浸润性导管癌组VEGF-C的表达和淋巴管的密度（LVD）都明显高于乳腺增生组（P〈0．01）；乳腺浸润性导管癌中VEGF-C阳性组中淋巴管的密度（11．32±5．78）与VEGF-C阴性组中的淋巴管密度（8．75±3．53），差别有统计学意义（P〈0．01）；乳腺浸润性导管癌中VEGF-C蛋白的表达和淋巴管密度（LVD）都与有无腋窝淋巴结转移及淋巴结转移个数有关（P〈0．05）。结论VEGF-C在乳腺浸润性导管癌淋巴管的生成中起着重要的作用；VEGF-C的高表达和淋巴管密度（LVD）的升高是促进乳腺导管癌淋巴结转移的重要的影响因素。
|
| 关 键 词： | 乳腺癌 淋巴结转移 血管内皮生长因子-C 淋巴管密度 |
VEGF-C EXPRESSION IN BREAST CARCINOMA AND ITS RELATIONSHIP WITH LYMPHANGIOGENESIS AND LYMPH NODE METASTASIS |
| |
| Liang Yunxia,Chen Maohuai,Huang Bo.VEGF-C EXPRESSION IN BREAST CARCINOMA AND ITS RELATIONSHIP WITH LYMPHANGIOGENESIS AND LYMPH NODE METASTASIS[J].Chinese Journal of Histochemistry and Cytochemistry,2008,17(6):594-598. |
| |
| Authors: | Liang Yunxia Chen Maohuai Huang Bo |
| |
| Institution: | Liang Yunxia,Chen Maohuai,Huang Bo(Department of Pathology,Medical College,Shantou University,Shantou 515031,China) |
| |
| Abstract: | Objective To investigate the expression of VEGF-C in breast carcinoma and its relationship with lymphangiogenesis and lymph node metastasis.Methods The expression of VEGF-C was detected by immunohistochemical staining in 21 cases of hyperplasia of mammary glands and 68 case of invasive ductal carcinoma.Lymphanigogenesis was examined by immunohistochemical staining with the specific D2-40 antibody and evaluated by lymphatic vessel density(LVD).Result The expression of VEGF-C and LVD were significantly higher... |
| |
| Keywords: | Breast carcinoma Lymph node metastasis VEGF-C LVD |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
