| 胃癌组织中溶菌酶的免疫组织化学及其与浸润转移的关系 |
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| 引用本文： | 谷化平,徐志勇,苏红,李春光,胡海霞.胃癌组织中溶菌酶的免疫组织化学及其与浸润转移的关系[J].中国组织化学与细胞化学杂志,1997(1). |
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| 作者姓名： | 谷化平 徐志勇 苏红 李春光 胡海霞 |
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| 作者单位： | 中国人民解放军２５１医院病理科 |
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| 摘 要： | 应用微波－ＳＰ法免疫组化技术，检测了９７例胃癌和３０例手术胃切端正常胃粘膜组织中溶菌酶（ＬＺＭ）表达状况。其阳性率分别为８５．６％和６６．７％，前者显著高于后者（Ｐ＜０．０５）。ＬＺＭ在胃癌中的表达阳性率比较，差分化癌和粘液细胞癌均显著高于分化型腺癌（Ｐ值均＜０．０５），有淋巴结转移性胃癌显著高于无淋巴结转移者（Ｐ＜０．００５）。在一组原发部位和淋巴结转移性胃癌配对标本中，ＬＺＭ表达无明显差异性，提示胃癌ＬＺＭ活性增高发生在淋巴结转移之前。结果表明，ＬＺＭ表达与胃癌细胞的分化程度及生物学行为密切相关
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| 关 键 词： | 胃癌 淋巴结转移 溶菌酶 免疫组织化学 |
THE RELATIONSHIP BETWEEN LYSOZYME IMMUNOHISTOCHEMISTRY AND THE INVASION AND METASTASIS OF GASTRIC CARCINOMA |
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| Abstract: | The expression of lysozyme in 97 cases of gastric cancer and 30 cases of normal gastric mucosa was examined by immunohistochemical SP technique with microwave. The result showed that the positive expresion rates of LZM were respectively 85 6% and 66 7%( P <0 05). The positive expresion of LZM rates in both low differential cancer and mucinous cancer were higher than those in high differential adenous cancer ( P <0 05). The expression of lysozyme in the gastric carcinoma with metastasis of lymph node was higher than that without metastasis ( P <0 05). There was no remarkable difference between primary site and metastatic lymph node in the patients with gastric cancer. This indicated that lysozyme activity was increased in gastric carcinoma before the oceurrence of the metastasis to lymph node. |
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| Keywords: | Carcinoma Metastasis to lymph node Lysozyme Immunohistochemistry |
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