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| ILK在肺鳞状细胞癌和肺腺癌的表达及其与临床病理特征和预后的关系 | |
| 引用本文： | 石蕊,于涓瀚,张道荣,景鑫,邱雪杉,王恩华.ILK在肺鳞状细胞癌和肺腺癌的表达及其与临床病理特征和预后的关系[J].中国组织化学与细胞化学杂志,2008,17(6):607-612. |
| 作者姓名： | 石蕊 于涓瀚 张道荣 景鑫 邱雪杉 王恩华 |
| 作者单位： | 1. 中国医科大学附属第一医院普通外科教研室,沈阳,110001 2. 中国医科大学病理教研室 3. 辽宁省沈阳市公安局刑警支队,沈阳,110001 |
| 摘 要： | 目的 探讨ILK在肺鳞状细胞癌和肺腺癌组织中的表达情况，及其与病理分型、肿瘤分化、分期、淋巴结转移及预后的关系。方法采用S-P免疫组织化学方法和Western Blot法，检测肺鳞状细胞癌和肺腺癌组织及相应癌旁肺组织中整合连接激酶（integrin-linkedkinase，ILK）的表达情况，并结合临床和病理资料进行分析。结果免疫组化结果显示：ILK在53／76（70％）的肺癌组织中阳性表达。其中鳞状细胞癌阳性率75％（33／44），腺癌阳性率62．5％（20／32），其表达与肺鳞状细胞癌的分化呈负相关（P〈0．01），与临床分期（P〈0．01）、淋巴结转移（P〈0．01）呈正相关；与肺腺癌的临床分期（P〈0．01）和淋巴结转移（P〈0．01）正相关，与分化程度无相关性（P〉0．05）。同时，其表达与患者的生存时间呈负相关（P〈0．01），与年龄、性别、肿瘤大小和组织类型等因素无关。Western Blot法进一步证实ILK在肺癌组织中的表达显著高于癌旁正常肺组织（P〈0．01），其表达与肺癌的分化（P〈0．01）显著负相关。结论肺鳞状细胞癌和肺腺癌中，ILK与肺癌的侵袭和转移有关。ILK可作为判断肺鳞状细胞癌和肺腺癌预后的参考指标。 |
| 关 键 词： | 肺 鳞状细胞癌 腺癌 整合素连接激酶 |
THE EXPRESSION OF INTEGRIN-LINKED KINASE IN LUNG SQUAMOUS CARCINOMA AND LUNG ADENOCARCINOMA AND ITS CORRELATION WITH CLINICAL PATHOLOGIC CHARACTER AND PROGNOSIS |
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| Shi Rui,Yu Juanhan,Zhang Daorong,Jing Xin,Qiu Xueshan,Wang Enhua.THE EXPRESSION OF INTEGRIN-LINKED KINASE IN LUNG SQUAMOUS CARCINOMA AND LUNG ADENOCARCINOMA AND ITS CORRELATION WITH CLINICAL PATHOLOGIC CHARACTER AND PROGNOSIS[J].Chinese Journal of Histochemistry and Cytochemistry,2008,17(6):607-612. | |
| Authors: | Shi Rui Yu Juanhan Zhang Daorong Jing Xin Qiu Xueshan Wang Enhua |
| Institution: | Shi Rui1,Yu Juanhan,2 Zhang Daorong2,Jing Xin3,Qiu Xueshan2,Wang Enhua2.(1Department of General Surgery,The First Affiliated Hospital,China Medical University,2Department of Pathology,3Shenyang Public Security Bureau,Shenyang 110001,China) |
| Abstract: | Objective To study the relationship between the expression of integrin-linked kinase(ILK)and some clinical pathological factors in human lung squamous carcinoma and lung adenocarcinoma.Methods Immunohistochemical method(S-P method)was adopted to detect the expression of ILK proteins in 44 cases of lung squamous carcinoma 32 lung adenocarcinoma and neighboring noncancerous tissues.ILK expressions in 30 fresh NSCLC samples was also determined with Western blot assay.Results Immunohistochemically,the overexpre... |
| Keywords: | Lung Squamous carcinoma Adenocarcinoma Integrin-linked kinase(ILK) |
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