| 限制性高脂饮食对大鼠多个器官Cx43表达的影响 |
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| 引用本文： | 谢雪梅,余上斌,刘声远,邹聪敏,杜颖,马万里,朱莉萍,赵建红,叶红.限制性高脂饮食对大鼠多个器官Cx43表达的影响[J].中国组织化学与细胞化学杂志,2010,19(2):140-146. |
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| 作者姓名： | 谢雪梅 余上斌 刘声远 邹聪敏 杜颖 马万里 朱莉萍 赵建红 叶红 |
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| 作者单位： | 1. 华中科技大学同济医学院病理生理系,武汉,430030
2. 华中科技大学同济医学院附属协和医院呼吸内科,武汉,430022 |
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| 摘 要： | 目的初步探讨限制性高脂饮食(脂肪含量高,热量摄入与对照一致)对大鼠多个器官Cx43蛋白表达的影响。方法Wistar大鼠52只分为普通饲料喂养组(雌雄各一组)、限制性高脂饲料喂养组(雌雄各一组),分别检测体重、Lee’s指数、血浆总胆固醇、血浆甘油三酯和血糖水平,用免疫组化检测大鼠各器官Cx43的蛋白表达。结果(1)普通饲料喂养组和限制性高脂饲料喂养组的体重、Lee’s指数、血糖、血脂均无显著性差异;(2)在雌性大鼠大脑皮质的神经元细胞、雌雄性海马区域的神经元细胞、雌性肝门管区和中央静脉周围细胞、雌雄性肾皮质近球小管上皮细胞、雌性髓袢粗段肾小管上皮细胞、雄性胰岛细胞、雄性睾丸间质限制性高脂饲料组Cx43蛋白表达明显强于普通饲料组;在雄性大鼠肝门管区和中央静脉周围细胞、雄性髓袢粗段肾小管上皮细胞、雌性胰岛细胞限制性高脂饲料喂养组Cx43表达明显弱于普通饲料组;雄性大鼠大脑皮质的神经元细胞两组无显著性差异。结论限制性高脂饮食可引起大鼠各器官Cx43差异表达。
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| 关 键 词： | 缝隙连接蛋白43 性别 限制性高脂饮食 |
EFFECT OF RESTRICTED HIGH FAT FEEDING ON CONNEXIN 43 EXPRESSION IN SOME ORGANS OF RATS |
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| Xie Xuemei,Yu Shangbin,Liu Shengyuan,Zou Congmin,Du Ying,Ma Wanli,Zhu Liping,Zhao Jianhong,Ye Hong.EFFECT OF RESTRICTED HIGH FAT FEEDING ON CONNEXIN 43 EXPRESSION IN SOME ORGANS OF RATS[J].Chinese Journal of Histochemistry and Cytochemistry,2010,19(2):140-146. |
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| Authors: | Xie Xuemei Yu Shangbin Liu Shengyuan Zou Congmin Du Ying Ma Wanli Zhu Liping Zhao Jianhong Ye Hong |
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| Institution: | Xie Xuemei1,Yu Shangbin1,Liu Shengyuan1,Zou Congmin1,Du Ying1,Ma Wanli2,Zhu Liping1,Zhao Jianhong1,Ye Hong1 (1Department of Pathophysiology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,2Department of Respiratory Diseases,Union Hospital,430022,China) |
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| Abstract: | Objective To examine the impact of restricted high fat feeding(high dietary fat content under isocaloric conditions),compared with a low fat diet,on connexin 43(Cx43) protein expressions in rat organs.Methods Male and female Wistar rats were exposed to one of two diets-control or high-fat restricted(HF-R,matched to the energy intake of control)-and were killed 13 weeks later.Body weight,Lee's index,blood glucose,plasma total cholesterol and triglyceride were observed,Cx43 protein expression in some organs w... |
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| Keywords: | Connexin 43 Sexuality Restricted high fat feeding |
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