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CK34βE12、P63和P504S在前列腺良恶性病变中的表达
引用本文:方长清,陆平,高艳华,蔡存伟,张道荣.CK34βE12、P63和P504S在前列腺良恶性病变中的表达[J].中国组织化学与细胞化学杂志,2008,17(1):30-33.
作者姓名:方长清  陆平  高艳华  蔡存伟  张道荣
作者单位:1. 中国医科大学基础医学院病理学教研室,中国医科大学附属第一医院病理科,沈阳,110001
2. 大庆市龙南医院病理科,黑龙江,163453
摘    要:目的探讨CK34βE12、P63和P504S在前列腺良恶性病变中的表达及鉴别诊断意义。方法应用免疫组化S-P法对57例前列腺癌及49例良性前列腺增生组织中CK34βE12、P63和P504S的表达水平及鉴别诊断意义。结果CK34βE12、P63和P504S在57例前列腺癌中的阳性表达率分别为1.7%及96.4%,P63为100%阴性表达;CK34βE12和P63在49例良性前列腺增生中阳性表达率分别为100%及100%,P504S为100%阴性表达。结论在前列腺增生性病变组织中联合检测CK34βE12、P63和P504S的表达对于前列腺良恶性病变鉴别诊断有重要意义。

关 键 词:前列腺癌  良性前列腺增生(BPH)  前列腺上皮内瘤(PIN)  P63  CK34βE12  P504S
修稿时间:2007年4月18日

EXPRESSIONS OF CK34βE12,P63 AND P504S IN BENIGN AND MALIGNANT PROSTATIC LESIONS
Fang Changqing,Lu Ping,Gao Yanhua,Cai Cunwei,Zhang Daorong.EXPRESSIONS OF CK34βE12,P63 AND P504S IN BENIGN AND MALIGNANT PROSTATIC LESIONS[J].Chinese Journal of Histochemistry and Cytochemistry,2008,17(1):30-33.
Authors:Fang Changqing  Lu Ping  Gao Yanhua  Cai Cunwei  Zhang Daorong
Institution:Fang Changqing,Lu Ping1,Gao Yanhua,Cai Cunwei,Zhang Daorong*(Deparment of Pathology,Department of Patholopy,The First Affiliated Hospital,China Medical University,Shenyang 110001,1Department of Pathology,Hospital of Daqing Longnan,Heilongiang 163453,China)
Abstract:Objective To study the expression and differential significance of CK34βE12, P63 and P504S in benign and malignant prostatic lesions. Methods S-P immunobistocbemical analysis was used to determine the expression levels of CK34βE12, P63 and P504S in 57cases of prostatic cancer and 49 cases of benign prostatic hyperplasia. Results The expressions of CK34βE12 and P504S in prostatic cancer was 1.7% positive and 96. 4% positive, while the expression of P63 was 100% negative; The expressions of CK34βE12 and P63 in benign prostatic hyperplasia was 100% and 100% positive, while the expression of P504S was 100% negative. Conclusion To distinguisb benign and malignant prostatic lesions, it is very significant to examine the expressions of CK34βE12, P63 and P504S combinedly in the byperplastic lesions of the prostate.
Keywords:Prostatic carcinoma  BPH  PIN  P63  CK34βE12  P504S
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