|
|||||
|
|
| 猕猴早期胚胎脑的发育与凋亡相关蛋白P53的表达 | |
| 引用本文： | 胡煜辉,梅盛平,董大翠,蒋裕芸,张艳,孙文化,刘子龙.猕猴早期胚胎脑的发育与凋亡相关蛋白P53的表达[J].中国组织化学与细胞化学杂志,2005,14(6):635-638. |
| 作者姓名： | 胡煜辉 梅盛平 董大翠 蒋裕芸 张艳 孙文化 刘子龙 |
| 作者单位： | 1. 井冈山学院解剖学教研室,吉安,343000 2. 湖北职业技术学院医学院解剖教研室,湖北,432000 3. 华中科技大学同济医学院解剖学系 4. 华中科技大学同济医学院计划生育研究所,武汉,430030 |
| 摘 要： | 目的探讨猕猴早期胚胎脑的发育及细胞凋亡相关蛋白P53的表达.方法建立猕猴早孕模型,获取早期胚胎,采用单克隆抗体链霉素亲生物蛋白过氧化酶 (SP)免疫组织化学方法,检测P53蛋白的表达.结果在猕猴25d、40d和55d胚胎脑均检测到P53免疫反应阳性神经细胞,随着胎龄的增加,P53免疫反应阳性表达率逐渐增大.结论在早期猕猴胚胎脑发育的不同时期内P53蛋白均有表达,并在胚胎脑发育过程中表达逐渐增加,调控脑的发育. |
| 关 键 词： | 发育 脑 猕猴 |
| 收稿时间： | 03 28 2005 12:00AM |
| 修稿时间： | 05 20 2005 12:00AM |
DEVELOPMENT OF THE EARLY EMBRYO BRAIN OF RHESUS MACAQUE ANDEXPRESSION OF APOPTOSIS-RELATED PRETEIN P53 |
|
| Hu Yuhui,Mei Shengping,Dong Dacui,Jiang Yuyun,Zhang Yan,Sun Wenhua,Liu Zilong.DEVELOPMENT OF THE EARLY EMBRYO BRAIN OF RHESUS MACAQUE ANDEXPRESSION OF APOPTOSIS-RELATED PRETEIN P53[J].Chinese Journal of Histochemistry and Cytochemistry,2005,14(6):635-638. | |
| Authors: | Hu Yuhui Mei Shengping Dong Dacui Jiang Yuyun Zhang Yan Sun Wenhua Liu Zilong |
| Institution: | Department o J Human Anatomy, Jinggangshan College , Jian, Jiangxi province , 343000; Department of Anatorny, Medical College, Hubei Vocational Technical College, Hubei 432000; 2Department of Human Anatomy ; 3 Institut of Family Planning, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
| Abstract: | Objective To investigate the development of the early embryo brain of Rhesus macaqueand the expression of apoptosis-related protein P53.Methods We established the early pregnant modeland tookembryos out,and used immunohistochemistry(SP)and computer image analysis to examinethe expression of P53 protein.Results The positive cells in the immunologic reaction werestained obviously in 25d,40d and 55d embryo brain ofRhesus macaque,and the expression of P53 was risingsignificantlywith the gestational age.Conclusion The expression of P53 proteinis observedin the brain ofRhesus monkeys at different periods of early embryo development and the expressionisincreased greatly with the development ofthe early embryo,which demonstrates that P53 proteinplays an important role in the regulation of the developmentof the early embryo brain. |
| Keywords: | P53 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |