| 大鼠纹状体GABA受体的表达及年龄性变化 |
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| 引用本文： | 彭建安,郭萍,瘳家万,王芳,刘向前,王小丽,刘胜洪.大鼠纹状体GABA受体的表达及年龄性变化[J].中国组织化学与细胞化学杂志,2008,17(3):323-326. |
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| 作者姓名： | 彭建安 郭萍 瘳家万 王芳 刘向前 王小丽 刘胜洪 |
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| 作者单位： | 1. 江西井冈山大学医学院解剖学系,江西,343300
2. 华中科技大学同济医学院基础医学院组织胚胎学教研室,武汉,430030 |
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| 摘 要： | 目的观察大鼠纹状体GABA受体的表达特征及增龄性变化。方法应用免疫组织化学及图像分析,Western blot观察大鼠纹状体GABARa受体的表达及年龄相关性变化。结果随着年龄的增加,大鼠纹状体GABAR阳性神经元及纤维明显增加,神经纤维排列紊乱,GABA免疫反应明显增强。结论老龄大鼠纹状体神经元GABAR的表达增加可能是一种有规律的增龄性变化。老年机体的某些抑制性精神症状可能与之有关。
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| 关 键 词： | γ氨基丁酸受体A 纹状体 神经元 老化 |
AGED-RELATED CHANGES IN THE EXPRESSION OF GABA RECEPTOR OF RAT STRIATUM |
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| Peng Jianan,Guo Ping,Liao Jiawan,Wang Fang,Liu Xiangqian,Wang Xiaoli,Liu Shenghong.AGED-RELATED CHANGES IN THE EXPRESSION OF GABA RECEPTOR OF RAT STRIATUM[J].Chinese Journal of Histochemistry and Cytochemistry,2008,17(3):323-326. |
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| Authors: | Peng Jianan Guo Ping Liao Jiawan Wang Fang Liu Xiangqian Wang Xiaoli Liu Shenghong |
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| Institution: | 1Peng Jianan,1Guo Ping,1Liao Jiawan,Wang Fang,Liu Xiangqian,Wang Xiaoli,Liu Shenghong(1Department of Anatomy,Medical Center of Jin-Gang Shan College of Jiangxi Province,Jiangxi 343300,Department of Histology , Embryology,Tongji Medical College,Huazhong University of Science , Technology,Wuhan 430030,China) |
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| Abstract: | Objective To observe the aged-related changes in the expression of GABA receptor of rat striatum.Methods Immunocytochemistry and Western blot were used to detect the expression and age-related change of GABAR in striatum.Results The number of GABAR positive neuron and nerve fibers were gradually increased in the striatum of rats from young to old age.GABAR positive fibers were distributed disorderly and intensity of GABAR immunohistochemistry was also increased with age.Conclusion The age-related increase o... |
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| Keywords: | GABAa receptor Striatum Neuron Ageing |
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