ras基因和表皮生长因子受体在胃癌中的表达及其病理临床意义

应用免疫组化方法检测ｒａｓ基因蛋白和表皮生长因子受体（ＥＧＦＲ）在７５例胃癌组织中的表达，研究它们与胃癌病理特征及预后关系。７５例胃癌ｒａｓ基因表达阳性率为４６．７％，与胃癌的分化程度，生长方式，浸润深度和淋巴转移呈明显正相关（Ｐ＜０．０５）；ＥＧＦＲ表达阳性率６１．３％，癌旁组织及新生血管有阳性表达；ＥＧＦＲ表达与胃癌大体类型，分化程度，生长方式和淋巴结转移呈正相关（Ｐ＜０．０５）；ｒａｓ蛋白表达与ＥＧＦＲ表达有明显关系（Ｐ＜０．０５）；Ｋａｐｌａｎ－Ｍｅｉｅｒ生存分析ｒａｓ蛋白和ＥＧＦＲ表达与胃癌的预后有明显的关系（Ｐ＜０．０１）。两者表达的检测有助于判断胃癌的恶性程度和预后估计。

EXPRESSION OF RAS GENE AND EGFR IN STOMACH CARCINOMA AND ITS SIGNIFICANCE IN PATHOLOGICAL CLINIC

Using immunohistochemical method the expression of ras gene protein and EGFR in 75 cases with stomach carcinoma was studied. The positive rate of expression in ras gene protein was 46 7%, which showed the positive correlation with the degree of differentiation, pattern of growth, depth of invasion and metastasis of lymph node ( P <0 05).The positive rate of expression in EGFR was 61 3%, especially appearing in side area and regenerated vessels of the carcinoma, and it possesses significant positive correlation with macrostructure type, differentiation, growth and metastases of lymph node and distant organs respectively ( P <0 05). The positive correlation appeared between ras gene protein and EGFR as well ( P <0 05). The Kaplan Meier's survival analysis showed that expressions of ras gene protein and EGFR were correlated significantly with the prognosis in stomach carcinoma so that it was considered helpful to the evaluation of its malignancy degree and prognosis.