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Survivin,Bcl-2在乳腺癌中的表达及意义
引用本文:谢平,阮秋蓉,李军川.Survivin,Bcl-2在乳腺癌中的表达及意义[J].中国组织化学与细胞化学杂志,2004,13(2):147-151.
作者姓名:谢平  阮秋蓉  李军川
作者单位:1. 华中科技大学同济医学院病理学系,武汉,430030
2. 湖北省荆州市第一人民医院病理科,湖北,434000
摘    要:目的探讨 Survivin,Bcl-2在乳腺癌中的表达及其与细胞凋亡和增殖的关系.方法用免疫组化S-P法检测60例乳腺癌中的Survivin, Bcl-2, PCNA的表达.并用TUNEL 法测定凋亡指数.结果 Survivin与病人的年龄、肿瘤的大小、组织学分级、淋巴结的转移无关,但与病人的生存期限有关;Bcl-2与乳腺癌组织学分级有关.Survivin与细胞的凋亡和增殖有关;Bcl-2只与细胞的凋亡有关.结论 Survivin与乳腺癌病人的生存期有关,可作为独立的预后因素;Survivin表达与Bcl-2表达之间无相关性,它们是通过不同途径发挥各自的生物学作用.

关 键 词:乳腺癌  免疫组织化学  TUNEL    凋亡指数
修稿时间:2003年11月27

EXPRESSION OF SURVIVIN AND Bcl-2 IN BREAST CARCINOMA AND THEIR SIGNIFICANCE
Xie Ping,Ruan Qiurong ,Li Junchuan.EXPRESSION OF SURVIVIN AND Bcl-2 IN BREAST CARCINOMA AND THEIR SIGNIFICANCE[J].Chinese Journal of Histochemistry and Cytochemistry,2004,13(2):147-151.
Authors:Xie Ping  Ruan Qiurong  Li Junchuan
Institution:Xie Ping,Ruan Qiurong *,Li Junchuan 1
Abstract:? Objective To research the expression of Survivin and Bcl-2 in breast carcinoma. Method The expression of Survivin, Bcl-2 and PCNA in 60 cases of breast carcinoma was detected by using S-P immunohistochemical method. Meanwhile, apoptosis was demonstrated by TUNEL method. Result Survivin expression was independent of the patient's age, tumor size, histological grade and nodal status, but it had a relationship with the patient's survival. The expression of Bcl-2 had only a relationship with the histological grade. Survivinexpression had a relationship with the apoptosis and proliferation of breast cancer while Bcl-2 expression was only related to apoptosis. Conclusion Survivin is an independent prognostic indicator of prognosis. There is no relationship between the expression of Survivin and that of Bcl-2. They exert their effect in different ways.
Keywords:Survivin
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