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球囊拉伤兔髂动脉内膜的组织形态变化的研究
引用本文:张曼,张海荣,康小玲,段玮,官影鹏,周爱儒,唐朝枢,汤健.球囊拉伤兔髂动脉内膜的组织形态变化的研究[J].中国组织化学与细胞化学杂志,1998(3).
作者姓名:张曼  张海荣  康小玲  段玮  官影鹏  周爱儒  唐朝枢  汤健
作者单位:海军总医院,北京医科大学心血管研究所
摘    要:球囊拉伤血管内膜是目前研究血管内膜增厚,管腔狭窄的方便而切实的模型。因此,对其演变过程的形态学研究是必要的。方法:应用PTCA球囊导管拉伤兔髂动脉,用光镜、电镜和扫描电镜观察拉伤后不同时间的动态变化。结果:拉伤后各期变化不同,拉伤后1周内,以血细胞沉积为主,1周后,内膜开始增生,2至4周增生最快。增生活跃的内膜平滑肌细胞来自活化的中膜平滑肌细胞。内皮细胞增生极慢,4周内未见内膜内皮化,呈虫食样改变。结论:球囊拉伤兔髂动脉内膜,可引起血栓形成,炎症反应,平滑肌细胞增生和细胞外基质堆积,导致血管腔狭窄。此研究为今后的工作提供一定的客观依据

关 键 词:球囊拉伤  血管内膜  增生

A MORPHOLOGIC STUDY OF ILIAC ARTERY INTIMA AFTER BALLOON INJURY IN RABBIT
Zhang Man\ Zhang Hairong,\ Kang Xiaoling,\ Guan Yingpeng, Zhou Airu,\ Tang Chaoshu,\ Tang Jian.A MORPHOLOGIC STUDY OF ILIAC ARTERY INTIMA AFTER BALLOON INJURY IN RABBIT[J].Chinese Journal of Histochemistry and Cytochemistry,1998(3).
Authors:Zhang Man\ Zhang Hairong  \ Kang Xiaoling  \ Guan Yingpeng  Zhou Airu  \ Tang Chaoshu  \ Tang Jian
Institution:Zhang Man\ Zhang Hairong,\ Kang Xiaoling,\ Guan Yingpeng,* Zhou Airu,\ * Tang Chaoshu,\ * Tang Jian
Abstract:Balloon injury vascular intima is the method used for studying vascular intima proliferation and restenosis. It is necessary to research the time course of the vascular injury morphogeny. Method: Rabbit iliac intima was injured by PTCA balloon, the time couse of the changes was observed by the light micrograph, electrograph, scanning electron micrograph. Results: There are different morphological changes in different stages. Blood cells were adhered to injured intima and the initial inflammatory response was characterized by these injured intima in 1 week after injury. Intima thickening and SMC proliferaton began at one week after injury. VSMC proliferation quickly increased in intima during 2-4 week after injury, these VSMC came from medium. But EC proliferaion was slow. There was no endothelialization in the surface of intima at 4th week. Conclusion: Balloon injury vascullar intima may cause thrombosis, inflammatory response, VSMC proliferation and matrix accumulation, which result in vascular stenosis. This study may provide some objective evidence for farther research.
Keywords:Balloon  injury  \ Vascular intima  \ Proliferation  
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