| 胃癌血管生成素和血管内皮生长因子的表达及其意义 |
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| 引用本文： | 郭冰沁,冯振中,俞岚,李涤臣.胃癌血管生成素和血管内皮生长因子的表达及其意义[J].中国组织化学与细胞化学杂志,2010,19(6):579-582. |
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| 作者姓名： | 郭冰沁 冯振中 俞岚 李涤臣 |
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| 作者单位： | 蚌埠医学院病理学教研室,蚌埠,233003 |
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| 基金项目： | 安徽省教育厅自然科学基金资助(KJ2007B389ZC) |
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| 摘 要： | 目的探讨血管内皮生长因子(VEGF)和血管生成素(angiopoietin,Ang)在胃癌的表达及其与肿瘤血管生成和临床病理因素的关系。方法采用免疫组化SP法检测84例胃癌和30例癌旁正常组织中VEGF、Ang-1、Ang-2的表达,应用CD34抗体标记微血管内皮细胞,计数微血管密度(MVD),结合临床病理资料进行分析。结果胃癌组织VEGF、Ang-2阳性表达率、MVD值明显高于癌旁正常组织(P(0.05)。VEGF表达与肿瘤大小、侵袭深度、临床分期、淋巴结转移有关(P(0.05),而与患者年龄、性别、组织学类型和分化程度无关,其阳性组的Ang-2阳性表达率、MVD值明显高于阴性组,VEGF的表达与Ang-2、MVD呈正相关。胃癌组织Ang-2表达与肿瘤大小、侵袭深度、淋巴结转移有关(P(0.05),与MVD呈正相关。胃癌Ang-1表达略低于对照组,但无统计学差异(P(0.05),Ang-1的表达与肿瘤侵袭深度和MVD值呈负相关。结论胃癌中VEGF、Ang-2蛋白的过度表达以及Ang-1蛋白的低表达可能在肿瘤血管生成和肿瘤浸润、转移中起重要作用。
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| 关 键 词： | 胃肿瘤 血管内皮生长因子 血管生成素 免疫组织化学 |
EXPRESSION AND SIGNIFICANCE OF ANGIOPOIETINS AND VEGF IN GASTRIC CANCER |
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| Guo Bingqin,Feng zhengzhong,Yu Lan,Li Dichen.EXPRESSION AND SIGNIFICANCE OF ANGIOPOIETINS AND VEGF IN GASTRIC CANCER[J].Chinese Journal of Histochemistry and Cytochemistry,2010,19(6):579-582. |
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| Authors: | Guo Bingqin Feng zhengzhong Yu Lan Li Dichen |
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| Institution: | Guo Bingqin,Feng Zhenzhong,Yu Lan,Li Dichen(Department of pathology,Bengbu Medical College,Bengbu 233030,China) |
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| Abstract: | Objective To investigate the expression of angiopoietins(Ang-1 /Ang-2) and vascular endothelial growth factor(VEGF) in gastric cancer,and to explore their relationship with angiogenesis and clinicopathological parameters.Methods The expressions of VEGF,Ang-1 and Ang-2 were detected by immunohistochemistry in 84 cases of primary gastric cancer and 30 cases of adjacent normal gastric mucosa.The microvessel density(MVD) was assayed by CD34-staining.Results The expressions of VEGF,Ang-2 and MVD were up-regulate... |
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| Keywords: | Stomach neoplasm Vascular endothelial growth factor Angiopoietin Immunohistochemistry |
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