| TTF-1和HBME-1在肺癌患者胸水中的表达及意义 |
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| 引用本文： | 蒋冰,吴明哲,吴广平,方长清,刘树立.TTF-1和HBME-1在肺癌患者胸水中的表达及意义[J].中国组织化学与细胞化学杂志,2008,17(3):274-278. |
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| 作者姓名： | 蒋冰 吴明哲 吴广平 方长清 刘树立 |
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| 作者单位： | 1. 中国医科大学附属第一医院病理诊断中心,沈阳,110001
2. 中国医科大学基础医学院病理教研室,沈阳,110001 |
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| 基金项目： | 沈阳市科技局技术创新开发研究基金
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辽宁省教育厅资助项目 |
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| 摘 要： | 目的探讨TTF-1和HBME-1在肺癌患者胸水中的诊断价值。方法应用免疫细胞化学方法（S-P）研究51例原发性肺癌患者和10例继发性肺癌患者胸水中的癌细胞及44例肺良性疾病胸水中反应性间皮细胞的表达。结果TTF-1在原发性肺癌患者胸水中的阳性率为78.4%（40/51）,而在继发性肺癌患者和肺良性疾病患者的胸水中未见阳性表达;HBME-1在肺良性疾病患者胸水中的阳性率95.5%（42/44）明显高于在原发性肺癌患者胸水中25.5%（13/51）和继发性肺癌患者胸水的阳性率20.0%（2/10）;在不同病理类型原发性肺癌患者胸水中,TTF-1的阳性率在腺癌组90.7%（39/43）明显高于鳞癌组12.5%（1/8）;当TTF-1和HBME-1联合应用时为最佳选择,其检测肺癌患者胸水的敏感性和特异性分别高达96.7%和95.5%。结论TTF-1和HBME-1对原发性、继发性肺癌患者胸水中癌细胞的诊断及鉴别诊断具有重要的临床应用价值。
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| 关 键 词： | 肿瘤标志物 肺肿瘤 胸水 甲状腺转录因子1 |
EXPRESSION AND SIGNIFICANCE OF TTF-1 AND HBME-1 IN PLEURAL FLUID OF PATIENTS WITH LUNG CANCER |
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| Jiang Bing,Wu Mingzhe,Wu Guangping,Fang Changqing,Liu Shuli.EXPRESSION AND SIGNIFICANCE OF TTF-1 AND HBME-1 IN PLEURAL FLUID OF PATIENTS WITH LUNG CANCER[J].Chinese Journal of Histochemistry and Cytochemistry,2008,17(3):274-278. |
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| Authors: | Jiang Bing Wu Mingzhe Wu Guangping Fang Changqing Liu Shuli |
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| Institution: | Jiang Bing,Wu Mingzhe,Wu Guangping,Fang Changqing1,Liu Shuli1(Department of Pathology,The First Affiliated Hospital,1Department of Pathology,College of Basic Medical Sciences,China Medical University,Shenyang 110001,China) |
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| Abstract: | Objective To investigate the diagnostic value of TTF-1 and HBME-1 in the pleural fluid of patients with lung cancer.Methods The expressions of TTF-1 and HBME-1 were examined by means of S-P immunocytochemical technique in cancer cells of pleural fluid from 51 patients with primary lung cancer and 10 patients with secondary lung cancer,and in reactive mesothelial cells of pleural fluid from 44 patients with benign lung diseases.Results The positive rate of TTF-1 in the cancer cells of pleural fluids of patie... |
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| Keywords: | Tumor markers Lung neoplasms Pleural fluid TTF-1 |
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