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| 口腔鳞状细胞癌中VEGF、Bcl-2的表达及意义 | |
| 引用本文： | 柴琳,陈乔尔,李倩,欧玉蓉,张洪福,周健.口腔鳞状细胞癌中VEGF、Bcl-2的表达及意义[J].中国组织化学与细胞化学杂志,2005,14(3):262-266. |
| 作者姓名： | 柴琳 陈乔尔 李倩 欧玉蓉 张洪福 周健 |
| 作者单位： | 1. 皖南医学院口腔系,芜湖,241000 2. 安徽医科大学附属口腔医院病理科,芜湖,241000 3. 安徽医科大学病理学教研室,芜湖,241000 |
| 摘 要： | 目的研究血管内皮细胞生长因子VEGF、Bcl-2在口腔鳞状细胞癌(OSCC)中的表达及意义。方法应用免疫组化SP法检测。结果在OSCC不同分化及TNM分期病例中VEGF阳性表达率无显著差异,但Ⅳ期VEGF阳性表达级别比Ⅰ期病例有显著增高。颈淋巴结转移组的VEGF比无颈淋巴结转移组阳性率高(P<0.05)。OSCC高分化组中Bcl-2的表达率比中低分化组明显低(P<0.05)。VEGF阳性级别越高的病例组,Bc-l2的表达率越高。结论在口腔鳞癌中VEGF、Bcl-2的表达有显著的正相关关系。 |
| 关 键 词： | 口腔鳞状细胞癌 血管内皮细胞生长因子 Bcl-2 |
| 修稿时间： | 2004年11月22 |
EXPRESSION AND SIGNIFICANCE OF VEGF AND BCL-2 IN ORAL SQUAMOUS CELLS CARCINOMA |
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| CHAI Lin,CHEN Qiaoer,Li Qian,Ou Yurong,ZHANG Hongfu,Zhou Jian.EXPRESSION AND SIGNIFICANCE OF VEGF AND BCL-2 IN ORAL SQUAMOUS CELLS CARCINOMA[J].Chinese Journal of Histochemistry and Cytochemistry,2005,14(3):262-266. | |
| Authors: | CHAI Lin CHEN Qiaoer Li Qian Ou Yurong ZHANG Hongfu Zhou Jian |
| Abstract: | Objective To study the significance of the expression of VEGF and Bcl-2 in oral squamous cell carcinoma. Methods The expression of VEGF and Bcl-2 was detected by immunohistochemistry (S-P method). Results There was no significant difference in the expression of VEGF in different TNM stages and pathologic grades of OSCC, but the degree of VEGF expression in the 4th TNM stage was higher than that in the other stages. There was a highly significant correlation between the expression of VEGF and the lymph node metastasis of OSCC (P<0.05). There was significant difference in the expression of Bcl-2 between cases of high and and those of moderate or low pathologic grades(P<0.05). The expression of Bcl-2 in cases of high degree VEGF expression was significantly higher than that in cases of low VEGF expression. Conclusion There is a significant positive correlation between the expressions of VEGF and Bcl-2 in OSCC. |
| Keywords: | Oral squamous cell carcinoma Vascular endothelial growth factor Bcl-2 |
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