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骨髓间充质干细胞外泌体中miRNA在视网膜新生血管形成中的作用及机制
引用本文:张璐,王雅芬,叶亚婷,白倩,郭长梅.骨髓间充质干细胞外泌体中miRNA在视网膜新生血管形成中的作用及机制[J].中国组织化学与细胞化学杂志,2022,22(6):936-940.
作者姓名:张璐  王雅芬  叶亚婷  白倩  郭长梅
作者单位:中国陕西省西安市,空军军医大学西京医院眼科 全军眼科研究所,中国陕西省西安市,空军军医大学西京医院眼科 全军眼科研究所,中国陕西省西安市,空军军医大学西京医院眼科 全军眼科研究所,中国陕西省西安市,空军军医大学西京医院眼科 全军眼科研究所,中国陕西省西安市,空军军医大学西京医院眼科 全军眼科研究所
基金项目:陕西省自然科学基础研究计划重点项目(No.2021JZ-30); 国家自然科学基金面上项目(No.81470655); 西京医院学科助推计划多学科综合诊疗项目(No.XJZT19MDT12)
摘    要:

视网膜血管疾病如早产儿视网膜病变、糖尿病视网膜病变和视网膜静脉阻塞等以异常增生的视网膜新生血管为主要病理表现。骨髓间充质干细胞来源外泌体通过旁分泌作用传递生物活性分子介导细胞间的物质与信息交换。其中,miRNA等内容物在传递信息中起关键作用,可调控缺血缺氧环境下内皮细胞的增殖、管腔形成和新生血管的形成。并且能够通过血视网膜屏障而不引起免疫、炎症反应,在眼科疾病治疗中极具潜力。本文总结骨髓间充质干细胞衍生外泌体中miRNA在视网膜新生血管形成中的作用和可能的作用机制,以期为外泌体在眼科疾病诊治中的应用拓宽新思路。

关 键 词:骨髓间充质干细胞    外泌体    miRNA    视网膜新生血管
收稿时间:2021/8/5 0:00:00
修稿时间:2022/4/27 0:00:00

The role and mechanism of miRNA in exosomes of bone marrow mesenchymal stem cells in retinal neovascularization
Lu Zhang,Ya-Fen Wang,Ya-Ting Ye,Qian Bai and Chang-Mei Guo.The role and mechanism of miRNA in exosomes of bone marrow mesenchymal stem cells in retinal neovascularization[J].Chinese Journal of Histochemistry and Cytochemistry,2022,22(6):936-940.
Authors:Lu Zhang  Ya-Fen Wang  Ya-Ting Ye  Qian Bai and Chang-Mei Guo
Institution:Department of Ophthalmology, Xijing Hospital, Fourth Military Medical of University, Xi''an 710032, Shaanxi Province, China,Department of Ophthalmology, Xijing Hospital, Fourth Military Medical of University, Xi''an 710032, Shaanxi Province, China,Department of Ophthalmology, Xijing Hospital, Fourth Military Medical of University, Xi''an 710032, Shaanxi Province, China,Department of Ophthalmology, Xijing Hospital, Fourth Military Medical of University, Xi''an 710032, Shaanxi Province, China and Department of Ophthalmology, Xijing Hospital, Fourth Military Medical of University, Xi''an 710032, Shaanxi Province, China
Abstract:Retinal vascular diseases such as retinopathy of prematurity, diabetic retinopathy, and retinal vein occlusion, and other retinal vascular diseases, with abnormal proliferation of retinal neovascularization as the main pathological manifestation. Exosomes derived from bone marrow mesenchymal stem cells transmit biologically active molecules through paracrine action to mediate the exchange of materials and information between cells. Among them, miRNA and other contents play key roles in transmitting information to regulate the proliferation of endothelial cells, the formation of the lumen, and new blood vessels in an ischemic and hypoxic environment. And it can cross the blood-retinal barrier without causing immune and inflammatory reactions and has great potential in the treatment of ophthalmic diseases. This article summarizes the role and possible mechanism of miRNA in bone marrow mesenchymal stem cell-derived exosomes in retinal neovascularization, with a view to broadening new ideas for the application of exosomes in the diagnosis and treatment of ophthalmic diseases.
Keywords:bone marrow mesenchymal stem cells  exosomes  miRNA  retinal neovascularization
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