| 红毛五加茎皮多糖对体外培养人白血病粒细胞生物学效应的研究 |
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| 引用本文： | 王满霞,张莅峡,刘红,张立石,刘泓,张海燕.红毛五加茎皮多糖对体外培养人白血病粒细胞生物学效应的研究[J].中国组织化学与细胞化学杂志,1994(1). |
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| 作者姓名： | 王满霞 张莅峡 刘红 张立石 刘泓 张海燕 |
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| 作者单位： | 中国中医研究院基础理论研究所 |
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| 摘 要： | 本文采用体外培养方法就红毛五加茎皮多糖对癌细胞生物学效应及其抗癌机制进行了初探。实验结果证明，红毛五加茎皮多糖具有良好的抗癌效果，能使体外培养的人白血病粒细胞形态明显改变，癌细胞生长受抑制，细胞生长曲线下降，细胞死亡率上升，流式细胞分光光度计测定分析，提示癌细胞合成ＤＮＡ的前期受到抑制，阻断ＤＮＡ的合成。
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| 关 键 词： | 红毛五加茎皮多糖，人白血病粒细胞，DNA周期，流式细胞分光光度计 |
THE STUDY OF BIOLOGICAL EFFECTS OF POLYHEXOSE FROM THE ACANTHOPANAX GIRAIDII HARMS ON HUMAN LEUKAEMIA CELL LINE (K562) |
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| Wang Manxia, Zhang Lixia, Liu Hong.THE STUDY OF BIOLOGICAL EFFECTS OF POLYHEXOSE FROM THE ACANTHOPANAX GIRAIDII HARMS ON HUMAN LEUKAEMIA CELL LINE (K562)[J].Chinese Journal of Histochemistry and Cytochemistry,1994(1). |
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| Authors: | Wang Manxia Zhang Lixia Liu Hong |
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| Abstract: | The effects of polyhexose on the K562 cell line were studied and we observed that the cell growth activity was inhibited by polyhexose in cell culture. By using FCM technique it was found that the DNA synthesis of K562 cell line in G1 phase, S phase and G+M phase was inhibited, whereas that of normal cell (embrynate prepuce fibrocyte) was not by polyhexose. |
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| Keywords: | Acanthopanax giradii harms effect K562 cell DNA cycle FCM technique |
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