| 移植骨髓间充质干细胞治疗大鼠糖尿病的研究 |
| |
| 引用本文： | 刘弘光,夏鲲,刘晓玉,庞希宁.移植骨髓间充质干细胞治疗大鼠糖尿病的研究[J].中国组织化学与细胞化学杂志,2007,16(1):104-109. |
| |
| 作者姓名： | 刘弘光 夏鲲 刘晓玉 庞希宁 |
| |
| 作者单位： | 中国医科大学细胞生物学卫生部重点实验室,基础医学院发育生物学教研室,沈阳,110001 |
| |
| 基金项目： | 辽宁省沈阳市科学技术计划课题 |
| |
| 摘 要： | 目的 通过移植骨髓间充质干细胞（mesenchymal stem cell，MSC）的方法试治疗大鼠糖尿病。方法 贴壁生长的MSC与大鼠胰腺的细胞共培养以检测其向胰岛细胞分化的潜能。并将体外培养扩增的MSC移植入糖尿病大鼠体内，观测其能否改善糖尿病病情及其在大鼠体内微环境中的分化情况。结果 共培养法可使MSC分化为胰岛样细胞。对大鼠的MSC移植能明显缓解糖尿病病情。结论 MSC移植的方法对大鼠糖尿病有一定的治疗作用。
|
| 关 键 词： | 骨髓间充质干细胞 胰腺细胞 共培养 糖尿病 细胞移植 |
| 文章编号： | 24307279 |
| 修稿时间： | 07 7 2006 12:00AM |
TRANSPLANTATION OF BONE MARROW MESENCHYMAL STEM CELLS PROMOTES FUNCTIONAL RECOVERY OF DIABETIC RATS |
| |
| Liu Hongguang,Xia Kun,Liu Xiaoyu,Pang Xining.TRANSPLANTATION OF BONE MARROW MESENCHYMAL STEM CELLS PROMOTES FUNCTIONAL RECOVERY OF DIABETIC RATS[J].Chinese Journal of Histochemistry and Cytochemistry,2007,16(1):104-109. |
| |
| Authors: | Liu Hongguang Xia Kun Liu Xiaoyu Pang Xining |
| |
| Institution: | Liu Hongguang, Xia Kun, Liu Xiaoyu, Pang Xining(Key Laboratory of Cell Biology of China＇s Ministry of Public Health, Department of Developmental Biology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China) |
| |
| Abstract: | Objective To observe the therapeutic effects of mesenchymal stem cells (MSCs) transplanted into diabetic rats. Methods Coculturing MSCs with pancreatic cells to observe the morphological changes and the expression of pancreas characteristic genes,transplanting MSCs into diabetic rats to examine their effects by monitoring the level of blood glucose, and detecting whether these MSCs could differentiate into pancreatic cells.Results MSCs differentiated into islet-like cells after coculturing with pancreatic cells, and the symptoms of diabetic rats were relieved. Conclusion MSC transplantation can relieve hyperglycemia in diabetic rats. |
| |
| Keywords: | Mesenchymal stem cell Pancreatic cell Coculture Diabetes Transplantation of cells |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
