| 大鼠甲状腺毒症心肌肥大的细胞内钙离子分布的研究 |
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| 引用本文： | 姜平,刘正清,梅璞,刘裕民,文建亚.大鼠甲状腺毒症心肌肥大的细胞内钙离子分布的研究[J].中国组织化学与细胞化学杂志,1999(2). |
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| 作者姓名： | 姜平 刘正清 梅璞 刘裕民 文建亚 |
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| 作者单位： | 湖南医科大学心血管形态研究室 |
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| 摘 要： | 采用人工大鼠腹腔注射Ｌ－甲状腺素３周、４周不等，发现实验组大鼠心肌细胞线粒体内有大量Ｃａ２＋沉淀物积聚，多呈弥漫性散在分布，亦可沿线粒体嵴呈线样排列。结果提示：细胞内Ｃａ２＋积聚和异常分布与细胞损害程度密切相关。
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| 关 键 词： | 甲状腺毒症心肌肥大 超微结构 Ca~(2＋)分布 电子探针 大鼠 |
A STUDY OF DISTRIBUTION OF INTERCELLULAR Ca 2+ IN MYOCARDIAL
HYPERTROPHY INDUCED BY THE THYROTOXICOSIS IN RATS |
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| Jiang Ping,Liu
Zhengqing,Mei Pu,Liu Yumin,Wen Jianya.A STUDY OF DISTRIBUTION OF INTERCELLULAR Ca 2+ IN MYOCARDIAL
HYPERTROPHY INDUCED BY THE THYROTOXICOSIS IN RATS[J].Chinese Journal of Histochemistry and Cytochemistry,1999(2). |
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| Authors: | Jiang Ping Liu
Zhengqing Mei Pu Liu Yumin Wen Jianya |
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| Abstract: | A total of 24 wistar rats were divided
into four groups: two experimental and two control groups. The myocardial hypertrophy was
induced in experimental rats by daily injections peritoneally of L thyroxine (1 0 mg/kg/day) for
3 or 4 weeks. Using the histochemical localization of Ca 2+ under electron microscope,
combined with microanalysis by electronprobe, we observed that Ca 2+ accumulation in
myocytes mitochondria of experimental rats was increased obviously. The results suggest that
damage of cardiac myocytes is closely related to Ca 2+ accumulation and abnormal
distribution in the cells. |
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| Keywords: | Thyrotoxic myocardial hypertrophy \ Ultrastructure\ Ca 2+ distribution \ Electron probe \ Rat |
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