Multiomics Reveals Ectopic ATP Synthase Blockade Induces Cancer Cell Death via a lncRNA-mediated Phospho-signaling Network期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Multiomics Reveals Ectopic ATP Synthase Blockade Induces Cancer Cell Death via a lncRNA-mediated Phospho-signaling Network

Institution:	1. Department of Life Science, Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan;2. Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan;3. Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan;4. Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan

Abstract:	Download : Download high-res image (256KB) Download : Download full-size image Highlights ?Ectopic ATP synthase as a therapeutic target for gefitinib-resistant NSCLC. ?Multiomics uncovers the dynamic network in response to ecto-ATP synthase blockade. ?Ecto-ATP synthase blockade induces cytotoxicity by CK2/phospho-topo IIα/GAS5 axis. ?A positive feedforward circuit between phospho-topo IIα and lncRNA-GAS5.

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