Quantitative Microproteomics Based Characterization of the Central and Peripheral Nervous System of a Mouse Model of Krabbe Disease期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Quantitative Microproteomics Based Characterization of the Central and Peripheral Nervous System of a Mouse Model of Krabbe Disease

Institution:	From 3NEST, Scuola Normale Superiore, Pisa 56127, Italy;;4Fondazione Pisana per la Scienza ONLUS, 56107 San Giuliano Terme, Pisa, Italy;;5NEST, Istituto Nanoscienze-CNR, Pisa, Italy;;6Neuroscience Institute-CNR, Pisa, Italy;;**Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

Abstract:	Download : Download high-res image (139KB) Download : Download full-size image Highlights •Quantitative microproteomics to study the CNS and PNS of the Twitcher mouse. •10plex TMT experiments on corpus callosum, motor cortex and sciatic nerves extracts. •More than 400 proteins groups deregulated between Twitcher and wildtype mice. •New insights into the molecular mechanisms of Krabbe disease.

Keywords:	Neurodegenerative diseases* Pathway Analysis Quantification Autophagy Inflammation Mass Spectrometry Mouse models Neurobiology* Protein Identification* laser capture microdissection TMT labeling
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