Ontogeny of human fetal catalase superoxide dismutase and lipid peroxidation: A comparative study |
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Authors: | Kathakali De Diptis Sengupta |
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Institution: | (1) Department of Biochemistry, University College of Science, University of Calcutta, 35, Ballygunge Circular Road, 700 019 Calcutta, India |
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Abstract: | A comparative study on the activity profile of catalase and superoxide dismutase, the two scavenging enzymes, as well as the
developmental profile of lipid peroxidation in the human fetal brain, liver and kidney have been done for gestation periods
ranging from 12 weeks to 28 weeks and beyond. The activity of the scavenging enzymes increase gradually inall the tissues with the advancement of pregnancy. Brain is an exception in case of catalase where the activity remains more
or less same throughout the developmental period except in the case of fetuses, 28 weeks and above where significant decrease
in the catalase activity is observed. A high level of lipid peroxidation is observed during early stages of development which
declines thereafter. |
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Keywords: | Catalase superoxide dismutase lipid peroxidation ontogeny antioxidant system |
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