Metabolism of echitamine and plumbagin in rats |
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Authors: | B Chandrasekaran B Nagarajan |
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Institution: | (1) Microbiology Division, Cancer Institute, 600 020 Madras |
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Abstract: | When administered to rats, echitamine was absorbed rapidly from the tissues and was detected in circulation within 30 min.
The drug level reached a maximum value by 2 h and then decreased steadily. The drug had completely disappeared from the blood
in 6 h. The presence of echitamine was observed within 2 h in urine and the maximum amount of drug was excreted between 2
and 4 h. About 90% of the drug was excreted in urine in 24 h and the drug could not be detected in urine after 48 h. Along
with echitamine, its metabolites were also detected in the urine. Plumbagin was not detected in blood upto 24 h when administered
into rats. The drug was detected in urine within 4 h after administration; a major portion of the drug was excreted in urine
by 24 h and traces of the drug were observed in the urine even after 48 h. |
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Keywords: | Echitamine plumbagin pharmacokinetics urinary metabolites plant extracts |
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