Aspernolides A and B, butenolides from a marine-derived fungus Aspergillus terreus |
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Authors: | Rajesh R Parvatkar Celina D’Souza Ashootosh Tripathi Chandrakant G Naik |
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Institution: | Bioorganic Chemistry Laboratory, National Institute of Oceanography, Council of Scientific and Industrial Research (CSIR), Dona Paula, Goa 403 004, India |
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Abstract: | Two aromatic butenolides, aspernolides A and B along with the known metabolites, butyrolactone I, terrein and physcion were isolated from the fermentation broth of a soft coral derived fungus Aspergillus terreus. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute stereochemistry of aspernolides A (1) and B (2) was established by their preparation from the known butyrolactone I. Biogenetically aspernolides A and B must be derived from butyrolactone I, a well known specific inhibitor of cyclin dependent kinase (cdk) from A. terreus. When tested, aspernolide A exhibited mild cytotoxicity against cancer cell lines. |
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Keywords: | Aspergillus terreus Marine natural products Butenolides Butyrolactone I Aspernolides |
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