|
|||||
|
|
Cytotoxic clerodane diterpenoids from the leaves of Premna tomentosa |
|
| Authors: | Chin Young-Won Jones William P Mi Qiuwen Rachman Ismail Riswan Soedarsono Kardono Leonardus B S Chai Hee-Byung Farnsworth Norman R Cordell Geoffrey A Swanson Steven M Cassady John M Kinghorn A Douglas |
| Institution: | Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA. |
| Abstract: | Three clerodane diterpenoids, premnones A-C (1-3), were isolated from a chloroform-soluble fraction of Premna tomentosa along with four known flavonoids and three known triterpenoids. Among these isolates, premnones A-C exhibited cytotoxic activity when evaluated against a small panel of tumor cell lines. However, premnone A was found to be inactive when evaluated in a follow-up in vivo hollow fiber assay at the highest dose tested (50mg/kg), using LNCaP, Lu1, and MCF-7 cells. |
| Keywords: | Premna tomentosa Verbenaceae Clerodane diterpenoids Premnones A-C Flavonoids Triterpenoids Cytotoxicity Hollow fiber assay |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |