Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia |
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| Authors: | Chen Wenliang Tang Weidong Lou Liguang Zhao Weimin |
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| Institution: | Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Department of Natural Products Chemistry, 555 Zuchongzhi Road, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China. |
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| Abstract: | 2alpha,7beta,20alpha-Trihydroxy-3beta,21-dimethoxy-5-pregnene (1), 6,7,9alpha-trihydroxy-3,8,11alpha-trimethylcyclohexo-d,e]-coumarin (2), 3beta-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid (3), and 3beta-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid methyl ester (4), along with 24 known compounds were isolated and structurally characterized from roots and aerial parts of Helicteres angustifolia (Sterculiaceae). In a preliminary bioassay, the two cucurbitacin derivatives, cucurbitacin D and J exhibited significant inhibitory activities against the growth of both hepatocellular carcinoma BEL-7402 cells and malignant melanoma SK-MEL-28 cells in vitro. |
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| Keywords: | Helicteres angustifolia Sterculiaceae Pregnane Coumarin Triterpenoid Cytotoxicity |
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