Derivatives of characiol,macrocyclic diterpene esters of the jatrophane type from Euphorbia characias

Eight non-irritant macrocyclic diterpene esters of the jatrophane type were obtained from an irritant acetone extract of latex and from an irritant methanol extract of roots of Euphorbia characias. They were shown to be diesters of the new parent alcohols characiol, characiol-5β,6β-oxide and 5β-hydroxyisocharaciol and pentaesters of 2,5β,8-trihydroxyisocharaciol.