Natural anti-HIV agents-part I: (+)-demethoxyepiexcelsin and verticillatol from Litsea verticillata |
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Authors: | Hoang Vu Dinh Tan Ghee Teng Zhang Hong-Jie Tamez Pamela A Hung Nguyen Van Cuong Nguyen Manh Soejarto D Doel Fong Harry H S Pezzuto John M |
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Institution: | Program for Collaborative Research in Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., Chicago, IL 60612, USA. |
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Abstract: | The eudesmane sesquiterpenoid, verticillatol (1), as well as the lignan, (+)-5'-demethoxyepiexcelsin (2), and a known lignan, (+)-epiexcelsin (3), were isolated from Litsea verticillata Hance. Lignan 2 showed moderate anti-HIV activity with an IC(50) value of 16.4 microg/ml (42.7 microM), while the known lignan 3 was inactive up to a concentration of 20 microg/ml (48.3 microM). Compound 1 demonstrated weak activity with an IC(50) value of 34.5 microg/ml (144.7 microM) while being devoid of cytotoxicity at 20 microg/ml. The structures were elucidated by 1D and 2D NMR spectroscopy, and the absolute configuration of the new sesquiterpenoid was determined by the generation of Mosher esters. |
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Keywords: | Litsea verticillata Lauraceae Verticillatol Sesquiterpene (+)-5′-Demethoxyepiexcelsin Lignan Sesquiterpene 2D NMR Absolute structure Anti-HIV activity HOG R5 Reporter cell line Green fluorescent protein |
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