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ent-Kaurene diterpenoids from Isodon oresbius |
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| Authors: | Xiang Wei Li Rong-Tao Wang Zong-Yu Li Sheng-Hong Zhao Qin-Shi Zhang Hong-Jie Sun Han-Dong |
| Institution: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. |
| Abstract: | Three new ent-kaurene diterpenoids, oreskaurins A-C (1-3), together with ten known ent-kaurene diterpenoids, enmenin monoacetate (4), effusanin E (5), adenolin B (6), maoecrystal G (7), enmelol (8), trichokaurin (9), sodoponin (10), trichorabdal A (11), nodosin (12), enmein (13), and a flavonoid, vitexin (14), were isolated from Isodon oresbius. Their structures were determined by spectroscopic means. Compound 12 showed inhibitory activity toward K562 cells with IC(50)=1.43 microg/ml. |
| Keywords: | Isodon oresbius Labiatae ent-Kaurenoid Oreskaurins A-C Cytotoxicity |
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