| 自组装短肽对角膜碱烧伤的作用 |
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| 引用本文： | 陈立艳,张颖慧,赵珍,盛宇,赵颖异,孙丽娟,赵晓军.自组装短肽对角膜碱烧伤的作用[J].四川动物,2009,28(1). |
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| 作者姓名： | 陈立艳 张颖慧 赵珍 盛宇 赵颖异 孙丽娟 赵晓军 |
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| 作者单位： | 四川大学纳米生物医学技术与膜生物学研究所,成都,610041 |
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| 摘 要： | 目的研究自组装短肽材料1%RADAl6-I水溶液对大鼠和兔角膜碱烧伤的作用.方法用1 mol/L NaOH溶液造SD大鼠和兔角膜碱烧伤模型,左眼每口滴加短肽水凝胶10μ1(2次/d),右眼为空白对照.在烧伤后的不同时间段(7、10、14d)处死大鼠,第7 d处死兔,取角膜行HE染色,光学显微镜观察结果.结果短肽水凝胶治疗组角膜上皮重生较快,皮下纤维排列较好,空白对照组皮下仍有较大空洞,皮下纤维排列紊乱,说明短肽材料能促进角膜恢复.
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| 关 键 词： | 角膜 碱烧伤 自组装短肽 |
Effect of Self-assembly Peptide for Corneal Alkali Burn |
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| CHEN Li-yan,ZHANG Ying-hui,ZHAO Zhen,SHENG Yu,ZHAO Ying-yi,SUN Li-juan,ZHAO Xiao-jun.Effect of Self-assembly Peptide for Corneal Alkali Burn[J].Sichuan Journal of Zoology,2009,28(1). |
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| Authors: | CHEN Li-yan ZHANG Ying-hui ZHAO Zhen SHENG Yu ZHAO Ying-yi SUN Li-juan ZHAO Xiao-jun |
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| Institution: | Institute for Nanobiomedical Technology and Membrane;Sichuan University;Chengdu 610041;China |
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| Abstract: | Objective To study the effect of the new-type material self-assembly peptide RADA16-I at the early stage after corneal alkali burn.Methods The SD rats and rabbits' eyes were burned with 1 mol/L NaOH solution and then applied 1%RADA16-I solution to the left eyes twice one day,while applied nothing to the right eyes.These rats were sacrificed on the 7th,10th,14th day after burn,while the rabbits on the 7th day,and the corneas were taken and then dyed with hematoxylin and eosin(HE).The photos were taken with m... |
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| Keywords: | cornea alkali burn self-assemly peptide |
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