| 银杏叶提取物对小鼠离体小肠平滑肌收缩特性的影响 |
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| 引用本文： | 王婧,潘盛武,杨盛昌.银杏叶提取物对小鼠离体小肠平滑肌收缩特性的影响[J].四川动物,2009,28(3). |
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| 作者姓名： | 王婧 潘盛武 杨盛昌 |
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| 作者单位： | 广西师范大学生命科学学院,广西桂林,541004 |
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| 摘 要： | 目的观察不同浓度的银杏叶提取物(Extract of Ginkgo biloba, EGb)对小鼠离体小肠平滑肌活动的影响,探讨EGb对小肠平滑肌的作用机制.方法制备离体肠段标本,灌流给药后记录不同浓度EGb作用下小肠收缩变化.结果低浓度和中浓度的EGb对离体小肠平滑肌有兴奋作用,随浓度增加,低浓度EGb的兴奋程度呈降低趋势,中浓度EGb的兴奋程度呈升高趋势;高浓度EGb引发抑制效应,随浓度增加,抑制程度降低.结论不同浓度范围的EGb对离体小肠平滑肌有不同作用,可能通过对平滑肌的直接作用或调节激素释放,影响离子通道等途径发挥作用.
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| 关 键 词： | 银杏提取物 小肠平滑肌运动 浓度依赖效应 |
Effects of Ginkgo biloba Extract on the Movement of Isolated Intestinal Smooth Muscle in Mice |
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| WANG Jing,PAN Sheng-wu,YANG Sheng-chang.Effects of Ginkgo biloba Extract on the Movement of Isolated Intestinal Smooth Muscle in Mice[J].Sichuan Journal of Zoology,2009,28(3). |
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| Authors: | WANG Jing PAN Sheng-wu YANG Sheng-chang |
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| Institution: | College of Life Sciences;Guangxi Normal University;Guilin;Guangxi Zhuang Autonomous Region 541004;China |
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| Abstract: | Objective To observe the effects of Ginkgo biloba extract at different concentrations on the movements of isolated intestinal smooth muscle in mice,and explore the mechanism of EGb on that.Methods The model of isolated intestinal smooth muscle in mice was established to record the movement changes of intestinal smooth muscle through drug perfusion.Results The low and middle concentrations of EGb both had excitation to isolated intestinal smooth muscle.As the concentrations of EGb increased,excitation induce... |
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| Keywords: | extract of Ginkgo biloba intestinal smooth muscle movement concentration-dependent effect |
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