化学药物对家兔离体小肠平滑肌电生理特性的影响

观察各种化学药物对家兔离体小肠各段平滑肌的作用,采用常规离体灌流的十二指肠、空肠及回肠平滑肌标本作舒缩运动实验,记录用药前后各段小肠平滑肌的收缩活动特征及变化规律.结果显示：不同浓度的乙酰胆碱和磷酸组织胺能增强小肠各段平滑肌的收缩频率与幅度,其幅值变化与用药前有显著性差异（P＜0.01） ,并呈剂量依赖性;而不同浓度的肾上腺素和阿托品则抑制小肠各段平滑肌（P＜0.01） .不同肠段对各种化学药物的作用存在着差异,一般十二指肠作用最强,空肠次之,回肠最差.

Effect of Chemical Drugs on Electrical Physiology Characteristics of the Isolated Smooth Muscle of Rabbits Small Intestine

To observe the effective mechanism of chemical durgs on the isolated smooth muscle of rabbits small intestine,the duodenum,jejunum and ileum smooth muscle were isolated by the routine experimental method from rabbits.The automatic contracting characteristic and changing pattern were recorded before and after drug taking.The results showed that: acetylcholine and histamine phosphate of different concentrations had a strengthening effect on automatic contracting activity of isolated smooth muscle and there were significant differences in frequency and scope before and after drug taking(P<0.01),and had dose-response dependent relationship.Adrenalinum and atropine of different concertration had a restraining effect on contracting frequency and scope of isolated smooth muscle of small intestine(P<0.01).The function in duodenum was the strongest,the next was jejunum and ileum the last.