Calcium-binding proteins and development |
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Authors: | Kathy Beckingham Alan Qing Lu Bernard F Andruss |
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Institution: | (1) Dept. Biochemistry and Cell Biology, Rice University, MS-140, P.O. Box 1892, Houston, TX, 77251-1892, U.S.A |
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Abstract: | The known roles for calcium-binding proteins in developmental signaling pathways are reviewed. Current information on the calcium-binding characteristics of three classes of cell-surface developmental signaling proteins (EGF-domain proteins, cadherins and integrins) is presented together with an overview of the intra-cellular pathways downstream of these surface receptors. The developmental roles delineated to date for the universal intracellular calcium sensor, calmodulin, and its targets, and for calcium-binding regulators of the cytoskeleton are also reviewed.© Kluwer Academic Publishers |
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Keywords: | calcium EGF-domains cadherins integrins calmodulin cytoskeleton Drosophila |
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