Effects of intraocular or systemic administration of neutralizing antibody against vascular endothelial growth factor on the murine experimental model of retinopathy |
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| Authors: | Sone H Kawakami Y Segawa T Okuda Y Sekine Y Honmura S Segawa T Suzuki H Yamashita K Yamada N |
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| Institution: | Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Japan. hsone@md.tsukuba.ac.jp |
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| Abstract: | Vascular endothelial growth factor (VEGF), the strongest known angiogenic cytokine and also a potent enhancer of vascular permeability, is closely associated with diabetic ocular complications and other intraocular neovascular diseases. The therapeutic effect of VEGF-neutralizing antibody on oxygen-induced retinopathy in an experimental murine model of proliferative retinopathy was investigated. Intraocular and systemic injection of the antibody resulted in 46% and 18% reductions in the number of nuclei of newly formed vessels of this model, respectively. The results demonstrated that a neutralizing antibody against VEGF was highly effective in the treatment of intraocular neovascularization and suggested possible modes of therapy in human intraocular neovascular diseases, including diabetic proliferative retinopathy. |
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