Sodium butyrate-induced changes in cultured rabbit articular chondrocyte transmembrane electrical potentials. Relationship between these changes and the proliferative response |
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| Authors: | S Larno M C Calvet J Calvet M Adolphe P Lechat |
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| Institution: | 1. Laboratoire de Pharmacologie Cellulaire de l''Ecole Pratique des Hautes Etudes et Laboratoire Associé 206 du CNRS, France;7. INSERM U3, Laboratoire d''Informatique Appliquée à la Neurobiologie, Ecole Pratique des Hautes Etudes Hôpital de la Salpêtrière, 47 boulevard de l''Hôpital 75013 Paris, France |
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| Abstract: | Sodium butyrate at 5mM reversibly induced a significant increase of transmembrane potentials (Em) in normal chondrocytes (24 hours after seeding) and arrested their proliferation. This increase in Em levels, which could be temporarily abolished by Tetra-ethyl Ammonium (TEA 5mM), was related to an increase in membrane permeability to K+. This hyperpolarization was correlated with the reversible inhibition of growth in G1 induced by the sodium butyrate. |
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