Ethanol and prostaglandin E1: Biochemical and behavioral interactions |
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| Authors: | John Rotrosen Donna Mandio David Segarnick LJ Traficante Samuel Gershon |
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| Institution: | Neuropsychopharmacology Research Unit Department of Psychiatry N.Y.U. School of Medicine 550 First Avenue New York, New York 10016, USA |
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| Abstract: | Low concentrations of ethanol enhanced prostaglandin (PG) E1-stimulated adenosine-3′, 5′-cyclic monophosphate (cAMP) accumulation in human platelets and in rat brain slices. Ethanol also potentiated platelet synthesis of PGE1 from dihomo-gamma-linolenic acid. These interactions may derive from the fluidizing effects of ethanol on lipid-containing cell membranes, and suggest a possible role for PGE1 as a mediator of certain acute effects of ethanol. The derivative possibility that “down regulation” of PGE1 systems is involved in the development of ethanol dependence is supported by data showing that PGE1 administered to mice following chronic exposure to ethanol reduced withdrawal syndrome intensity. |
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