Kinetic analysis of the shift of aerobic to anaerobic metabolism in rats during acute cyanide poisoning |
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| Authors: | Yoshinao Katsumata Keizo Sato Masakazu Oya Osamu Suzuki Masataka Yoshino |
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| Institution: | 1. Department of Legal Medicine, Nagoya University School of Medicine, Nagoya 466, Japan;2. Department of Legal Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-31, Japan;3. Department of Biochemistry, Yokohama City University School of Medicine, Yokohama 232, Japan |
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| Abstract: | Blood concentrations of cyanide, lactate, glucose, oxypurines and allantoin were determined in rats sampled at 10 min after the intraperitoneal administration of various concentrations of potassium cyanide. Lactate and oxypurines in plasma increased biquadratically with increase in the cyanide concentration in blood. The concentrations of cyanide for half maximal effect were 1.63 μg/ml for lactate and 2.09 μg/ml for oxypurines. Plasma glucose increased quadratically with increase in the cyanide concentration, and the marked increase was observed where plasma lactate concentration became near maximal. Plasma allantoin concentrations were not significantly changed throughout the experiments. The present results indicate that determination of plasma oxypurines as well as lactate is an excellent parameter for tissue hypoxia. |
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