Meal feeding schedule and ventromedial hypothalamic lesions do not affect rhythm of pineal serotonin N-acetyltransferase activity in rats |
| |
| Authors: | K Nagai K Yamazaki H Tsujimoto S Inoue H Nakagawa |
| |
| Institution: | 1. Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Osaka (565), Japan;1. Third Department of Internal Medicine, Medical School, Yokohama City University, Yokohama, Kanagawa, (232), Japan |
| |
| Abstract: | Effects of meal feeding schedule and bilateral lesions of the ventromedial hypothalamus (VMH) on the circadian rhythm of pineal serotonin N-acetyltransferase (SNAT) activity were examined in rats, under LD (12:12) condition. Neither meal feeding nor VMH lesions affected the phase of the circadian rhythm of pineal SNAT activity, but the VMH lesions reduced the level. Meal feeding caused a shift of the phases of the daily rhythms of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase activities in the liver. These findings suggest that the circadian rhythm of pineal SNAT activity is not entrained by the food intake, and that the VMH does not function as a master oscillator of the rhythm. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
