Differetial sensitivity of spontaneously hypertensive rats to the hypothermic effect of dopaminergic drugs |
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| Authors: | John R Martin Raymond M Quock |
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| Institution: | Department of Physiology/Pharmacology, School of Pharmacy, University of the Pacific, Stockton, California 95211, USA |
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| Abstract: | The dopaminergic agonist apomorphine produces dose-related hypothermia in naive rats as does L-DOPA in carbidopa-pretreated rats. The hypothermic responses to these two dopaminergic drugs were significantly more pronounced and prolonged in the spontaneously hypertensive rat than in normotensive Wistar control rats. The greater sensitivity of the SHR to these drugs was reflected as a leftward shift of the dose-response curves for apomorphine- and L-DOPA-induced hypothermias. |
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