Biochemical examination on the increased superoxide dismutase-like plasma substance observed in a state of acute gastric mucosal lesions |
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Authors: | T Ohara K Matsuda D Shibuya Y Eda T Yuki S Asaki T Toyota T Kurokawa R Sasaki |
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Institution: | Third Department of Internal Medicine, School of Medicine, Tohoku University, Sendai, Japan. |
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Abstract: | When experimental acute gastric mucosal lesions were produced in guinea pig by water-immersion and restraint stress, superoxide dismutase (SOD)-like substance in the plasma increased. On analysis by gel filtration, it was shown that the molecular weight of the increased SOD-like plasma substance was about 130,000, and even after treatment with trypsin, 84% of this substance remained. Since the molecular weight of intracellular SOD is about 40,000, it seems that this substance is similar to extracellular SOD, located on the endothelial cell-surface, as previously reported by Marklund et al. Our results suggest that in the presence of acute gastric mucosal lesions, SOD-like plasma substance is not identical to intracellular SOD, which derived from cell destruction by stress or free radical-induced microvascular damage or by hemolysis. Furthermore, this substance may itself work as a scavenger of free radicals generated under conditions, such as these described in the present experiment. |
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