Carnitine transport by rat kidney cortex slices: stimulation by dibutyryl cyclic AMP+. |
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Authors: | P J Huth J H Thomsen A L Shug |
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Institution: | Metabolic Research Laboratory, William S. Middleton Memorial Veterans Administration Hospital 2500 Overlook Terrace, Madison, Wisconsin 53705, USA |
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Abstract: | The transport of carnitine by rat kidney cortex slices against a concentration gradient has been demonstrated. Similarities to other transport systems included a linear period of uptake, as well as indications of saturability of the system with increasing concentrations of substrate. The transport of carnitine was inhibited by anoxia, and carbonyl cyanide-m-chloro-phenylhydroxazone (CCC1P), an uncoupler of oxidative phosphorylation. Carnitine uptake was stimulated approximately 50% when kidney slices were treated with dibutyryl cAMP. |
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Keywords: | Address correspondence to this author |
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