| 地塞米松诱发的大鼠胰岛素抵抗模型 |
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| 作者姓名： | Zhang FL Liu XY Linn YC Zhang KZ |
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| 作者单位： | 1. 福建医科大学附属协和医院,福建内分泌研究所,福建,福州,350001;上海第二医科大学附属瑞金医院,上海市内分泌研究所,上海,200025
2. 福建医科大学附属协和医院,福建内分泌研究所,福建,福州,350001 |
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| 基金项目： | 福建省卫生厅青年基金资助课题 (Q98 1 19) |
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| 摘 要： | 目的：建立一种简便可靠的大鼠胰岛素抵抗模型。方法：对大鼠进行不同剂量地塞米松腹腔注射，观察不同时间各组大鼠糖代谢相关变化。结果：大鼠空腹葡萄糖、胰岛素、胰岛素抵抗程度呈地塞米松给药时间及剂量依赖性，后两者改变先于前者改变。结论：一定剂量的地塞米松空腹注射将诱发大鼠胰岛素抵抗，这种模型简便、可靠，可用于相关课题的研究。
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| 关 键 词： | 胰岛素抵抗 地塞米松 大鼠 模型 |
| 文章编号： | 1000-6834(2002)01-0098-03 |
Insulin resistance model induced by dexamethasone in rats |
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| Zhang FL,Liu XY,Linn YC,Zhang KZ.Insulin resistance model induced by dexamethasone in rats[J].Chinese Journal of Applied Physiology,2002,18(1):98-100. |
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| Authors: | Zhang Fang-Lin Liu Xiao-Ying Linn Yi-Chuan Zhang Kai-Zhen |
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| Institution: | ZHANG Fang-lin 1,2,LIU Xiao-ying 1,LIN Yi-chuan 1,ZHANG Kai-zhen 1 |
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| Abstract: | Aim:To build a easy and reliable rat model of insulin resistance. Methods:Changes concerning sugar metabolism were observed in experimental rats injected intraperitoneally by different doses of dexamethasone. Results:The changes by dexamethasone in fasting blood insulin and insulin resistance prior to that of fasting blood glucose were dose and time dependent. Conclusion:It was convenience to set up a insulin resistance model induced by dexamethasone in rats which would favor other related research. |
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| Keywords: | insulin resistance dexamethasone rats |
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