| ET－1，NO和缺氧对肺动脉平滑肌细胞钙内流及胶原合成的影响 |
| |
| 引用本文： | 冯晓东,蔡英年,邓希贤.ET－1，NO和缺氧对肺动脉平滑肌细胞钙内流及胶原合成的影响[J].中国应用生理学杂志,1996(3). |
| |
| 作者姓名： | 冯晓东 蔡英年 邓希贤 |
| |
| 作者单位： | 中国医学科学院中国协和医科大学基础医学研究所 |
| |
| 基金项目： | 八五国家攻关课题,中科院低氧生理开放实验室基金 |
| |
| 摘 要： | 肺血管平滑肌细胞是肺血管收缩反应的主要执行者，也是肺血管结构重建的重要参与者。本研究观察了内皮素１（ＥＴ１），一氧化氮（ＮＯ）和缺氧对培养的新生小牛肺动肺平滑肌细胞（ＰＡＳＭＣ）钙内流以及胶原合成的影响。结果表明ＥＴ１和缺氧可促进ＰＡＳＭＣ的钙内流，ＮＯ供应剂硝普钠（ＳＭＰ）可抑制ＥＴＩ诱导的钙内流，其作用呈剂量依赖性，ＳＮＰ还可以剂量依赖地抑制ＰＡＳＭＣ的胶原合成，而缺氧可促进ＰＡＳＭＣ的胶原合成。
|
| 关 键 词： | 肺动脉平滑肌细胞 钙内流 胶原合成 |
EFFECT OF ET 1, NO AND HYPOXIA ON CALCIUM INFLUX AND COLLAGEN SYNTHESIS OF PULMONARY ARTERY SMOOTH MUSCLE CELLS |
| |
| Feng Xiaodong,Cai Yingnian,Deng Xixian.EFFECT OF ET 1, NO AND HYPOXIA ON CALCIUM INFLUX AND COLLAGEN SYNTHESIS OF PULMONARY ARTERY SMOOTH MUSCLE CELLS[J].Chinese Journal of Applied Physiology,1996(3). |
| |
| Authors: | Feng Xiaodong Cai Yingnian Deng Xixian |
| |
| Abstract: | Pulmonary vascular smooth muscle cell is an important executor of vasoconstriction and a key contributor of pulmonary vascular structure remodeling. In this study, we observed the effect of endothelin 1 (ET 1), nitric oxide (NO) and hypoxia on calcium influx and collagen synthesis of cultured new born calf pulmonary artery smooth muscle cells (PASMC). The results indicated that ET 1 and hypoxia stimulated calcium influx of PASMC, and sodium nitroprusside (SNP), a donor of NO, inhibited calcium influx of PASMC induced by ET I in a dose dependent manner. SNP also inhibited collagen synthesis of PASMC, but hypoxia stimulated collagen synthesis of PASMC. All these suggested that ET 1, NO and hypoxia may be important to the pathogenesis and development of hypoxic pulmonary hypertension (HPH). |
| |
| Keywords: | pulmonary artery smooth muscle cells calcium influx collagen synthesis |
| 本文献已被 CNKI 等数据库收录！ |
|
