纳洛酮对大鼠烫伤休克的影响

36只烫伤大鼠,分为纳洛酮组和盐水对照组。两组动物侧脑室分别注射纳洛酮和生理盐水,观察纳洛酮对烫伤休克的影响。 结果表明:纳洛酮组大鼠的存活率高于盐水对照组。纳洛酮组动物烫伤后2小时存活率为83％,烫伤后4小时存活率为39％;盐水组动物烫伤后2小时存活率为44％,烫伤后4小时存活率为5.6％。纳洛酮组血压下降和心率减慢的进度也较慢,烫伤后180分钟血压才降低到63％,而盐水组在烫伤后90分钟血压已降低到62％。纳洛酮组动物的呼吸和体温变化也较慢。这些结果提示:纳洛酮具有一定的抗烫伤休克的作用。

THE EFFECT OF NALOXONE ON THE BURN SHOCK IN RAT

36 burned rats were divided into naloxone group and saline group.Nalo-xone and saline were injected into lateral ventricle in these two groups, to observe the effect of naloxnne on the burn shock in rat.The results showed that survival rate of naloxone-treated rats was much higher than that of saline-treated animals. In naloxone group, two and four hours after burn, survival rates were 83% and 39% respectively, and in saline group, only 44% and 5.6% respectively. The course of hypotension and bradycardia were slowly in naloxone group.The blood pressure of naloxone group was reduced by 63% at 180 minutes after burn, and in saline group, the blood pressure was reduced by 62% at 90 minutes after burn. The changes of respiration and body temperature were also more slowly in naloxone group. These findings suggest that naloxone may have a role to antagonise burn shock.