蓝斑对迷走─心血管反射的影响

实验用家兔３６只，采用低频（５－８Ｈｚ）和高频（５０－１００Ｈｚ）电流刺激颈部迷走神经中枢端（ＶＡＳ），建立迷走－减压和迷走－升压反射，两种频率电刺激均导致肾交感神经传出活动（ＲＳＡ）减少。以迷走－血压反射和迷走－交感反射为指标，连续电流刺激蓝斑（ＬＣ）或ＬＣ微量注射谷氨酸钠均抑制迷走－血压反射和迷走－交感反射。而连续电流刺激ＬＣ或ＬＣ微量注射谷氨酸钠本身均引起平均动脉血压升高和ＲＳＡ增加。本文对新近提出的对ＬＣ整体功能认识的理论，结合本文的结果进行了讨论

INFLUENCE OF LOCUS COERULEUS STIMULATION ON THE VAGAL CARDIOVASCULAR REFLEX

Experiments were performed on 36 anesthetized rabbits. By cervical vagal afferent stimulation (VAS) with lower electric frequency (5 8 Hz) and higher electric frequency (50 100 Hz), the depressor and pressor responses were established. Both of these responses accompanied by decreasing in renal sympathetic activity (RSA).With the parameters of vagal pressure reflex and vagal sympathetic stimulation reflex,effects of stimulation of the locus coeruleus on these were investigated. The vagal pressure and sympathetic reflexes were significantly inhibited by electric and chemical (glutamate) stimulation of the locus coeruleus. Meanwhile both the electric and chemical stimulation of the locus coeruleus per se elicited the elevation of BP and RSA. These results together with the recently hypothesized global function of the locus coeruleus were discussed.