蓝斑对迷走—心血管反射的影响

实验用家兔３６只，采用低频和高频电流刺激颈部迷走神经中枢端，建立迷走－减压和迷走－升压反射，两种频率电刺激均导致肾交感神经传出活动减少。以迷走－血压反射和迷走－交感反射为指标，连续电流刺激蓝斑或ＬＣ微量注射谷氨酸钠均抑制迷走－血压反射和迷走－交感反射。

Influence of locus coeruleus stimulation on the vagal-cardiovascular reflex]

Experiments were performed on 36 anesthetized rabbits. By cervical vagal afferent stimulation (VAS) with lower electric frequency (5-8 Hz) and higher electric frequency (50-100 Hz), the depressor and pressor responses were established. Both of these responses accompanied by decreasing in renal sympathetic activity (RSA). With the parameters of vagal-pressure reflex and vagal-sympathetic stimulation reflex, effects of stimulation of the locus coeruleus on these were investigated. The vagal-pressure and sympathetic reflexes were significantly inhibited by electric and chemical (glutamate) stimulation of the locus coeruleus. Meanwhile both the electric and chemical stimulation of the locus coeruleus per se elicited the elevation of BP and RSA. These results together with the recently hypothesized global function of the locus coeruleus were discussed.