| 中脑导水管周围灰质内神经降压素在电针镇痛中的作用 |
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| 引用本文： | 刘文彦,白波.中脑导水管周围灰质内神经降压素在电针镇痛中的作用[J].中国应用生理学杂志,1997,13(3):253-256. |
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| 作者姓名： | 刘文彦 白波 |
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| 作者单位： | 济宁医学院生理学教研室，第二军医大学神经生物学教研室 |
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| 摘 要： | 本工作以钾离子透入法引起大鼠甩尾反应的电流强度为痛反应指标，测定动物痛阈，观察到大鼠中脑导水管周围灰质（ＰＡＧ）内注入神经降压素（ＮＴ）后，大鼠痛阈和电针镇痛效应明显升高；注入抗神经降压素血清后，痛阈和电针镇痛效应明显降低。注入纳洛酮后，可明显减弱ＮＴ镇痛和电针镇痛的效应。提示，ＰＡＧ内ＮＴ参与电针镇痛的病理生理过程，且至少部分效应是通过内源性阿片肽系统中介的
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| 关 键 词： | 神经降压素 抗神经降压素血清 纳洛酮 电针镇痛 |
THE ROLE OF PERIAQUEDUCTAL GRAY NEUROTENSIN IN ELECTROACUPUNCTURE ANALGESIA |
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| Liu Wenyan,Bai Bo,Song Chaoyou ,Wang Shuguang,Shi Weiqing.THE ROLE OF PERIAQUEDUCTAL GRAY NEUROTENSIN IN ELECTROACUPUNCTURE ANALGESIA[J].Chinese Journal of Applied Physiology,1997,13(3):253-256. |
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| Authors: | Liu Wenyan Bai Bo Song Chaoyou Wang Shuguang Shi Weiqing |
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| Institution: | Department of Physiology, Jining Medical College. |
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| Abstract: | The effect of periaqueductal gray (PAG) injection of neurotensin (NT), anti NT serum (ANTS), and naloxone (Nx) on both the pain threshold and electroacupuncture (EA) analgesia in rat was investigated in this study. The potassium iontophoresis induced tail flick was used to measure the pain threshold. NT administraiton induced an increase in pain threshold and enhanced EA analgesia. Injection of ANTS reduced the pain threshold significantly and diminished the effect of EA analgesia. Furthermore,pre injection of Nx into PAG could weaken analgesia effect of NT and NT EA analgesia. These results indicate that NT in PAG is involved in pain modulation and plays a role in EA analgesia. The effect of NT may be partly conducted by endogenous opiate peptides. |
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| Keywords: | neurotensin anti neurotensin serum naloxone electroacupuncture analgesia |
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