| 超氧化物歧化酶对创伤小鼠淋巴细胞膜流动性及功能的影响 |
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| 引用本文： | 罗艳,梁华平.超氧化物歧化酶对创伤小鼠淋巴细胞膜流动性及功能的影响[J].中国应用生理学杂志,1997,13(4):309-311. |
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| 作者姓名： | 罗艳 梁华平 |
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| 作者单位： | 第三军医大学野战外科研究所 |
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| 摘 要： | 研究了超氧化物歧化酶（ＳＯＤ）对创伤小鼠淋巴细胞膜流动性及功能的影响。结果显示，ＳＯＤ体内应用（１００００Ｕ／ｋｇｄ，伤后０－３ｄ）可明显降低创伤小鼠血清、脾脏、胸腺、肠系膜淋巴结组织及Ｔ细胞中丙二醛（ＭＤＡ）含量，提高淋巴细胞膜及Ｔ细胞质膜、线粒体膜、微粒体膜的流动性，对创伤后Ｔ细胞转化活性降低、白细胞介素２（ＩＬ－２）生成减少、ＩＬ－２受体（ＩＬ－２Ｒ）表达受抑、ＩＬ－２介导的淋巴细胞增殖反应（ＩＬ－２ＭＬＰＲ）降低均具有不同程度的恢复作用。表明ＳＯＤ可保护创伤后淋巴细胞免受氧自由基的损害，并提高淋巴细胞的功能。
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| 关 键 词： | 超氧化物歧化酶 创伤 淋巴细胞 膜流动性 |
Effect of superoxide dismutase on membrane fluidity and functions of lymphocytes in traumatized mice] |
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| Y Luo,H Liang,Z Wang,B Geng,X Xu.Effect of superoxide dismutase on membrane fluidity and functions of lymphocytes in traumatized mice][J].Chinese Journal of Applied Physiology,1997,13(4):309-311. |
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| Authors: | Y Luo H Liang Z Wang B Geng X Xu |
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| Institution: | Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing. |
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| Abstract: | Effect of superoxide dismutase (SOD) on membrane fluidity and functions of lymphocytes in traumatized mice was studied. The results showed that in vivo administration of SOD (10,000 U/kg.d, from 0 to 3 days posttrauma) could significantly decrease malondialdehyde (MDA) contents in serum, lymphatic tissues from spleen, thymus, mesenteric lymph nodes and T cells plasmalemma, mitochondria, microsome, restore decreased T lymphocytes and T cells in traumatized mice, elevate membrane fluidity of lymphocytes transformation (TLT), reduce interleukin 2 (IL-2) production, supprssed IL-2 receptor (IL-2R) expression and depress IL-2 mediated lymphocyte proliferation response (IL 2MLPR) after trauma in various degress. It is suggested that SOD may protect lymphocytes post trauma from damage of oxygen free radical, and elevate lymphocytes functions. |
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